A2M Protein
Product Sizes
200µg
OPPA01428-200UG
About this Product
- SKU:
- OPPA01428
- Additional Names:
- A2MD; CPAMD5; FWP007; S863-7
- Extra Details:
- Alpha-2 Macroglobulin is a serine proteases inhibitor; which inhibits coagulation by inactivating thrombin and Kallikrein; it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein; which is produced by the liver; it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-; cysteine-; aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait†region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size; A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis; pregnancy and diabetes.
- Molecular Weight:
- 725 kDa
- Protein Details:
- Alpha-2-macroglobulin
- Purity:
- > 95% as determined by Analysis by SDS-PAGE
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- It is recommended to reconstitute the lyophilized A2M in sterile 18M-omega-cm H2O. Lyophilized A2M protein; although stable at room temperature for 3 weeks; should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long-term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:html_datasheet.php
