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Antibodies

Anti-Rt CD8b Purified Low Endotoxin

Product Sizes
0.1 mg
12-656-0.1MG
About this Product
SKU:
12-656
Application:
Cell-based/Functional Assay, Flow Cytometry, IHC-Frozen, Immunoprecipitation, Western Blot
CE/IVD:
RUO
translate.label.attr.clone:
341
Concentration:
1 mg/ml
Extra Details:
The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Immunogen:
CD8 positive Wistar rat splenic T cell hybridomas
Isotype:
IgG1, kappa
Reactivities:
Rat
Shipping Conditions:
Ambient
Specificity:
The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
Storage Conditions:
2-8[o]C Do not freeze.
Supplier:
Exbio
Type:
Antibody