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Breaking new ground with Daicel Arbor - Cryptosporidium

Some of our colleagues at Daicel Arbor have released their latest preprint as part of their research group "Whole Genome Targeted Enrichment And Sequencing of Human-Infecting Crytosporidium spp" In this pre-print, they detail their journey developing an innovative panel with the goal of enriching RNA across the whole Cryptosporidium spp genome. Currently, this goal is difficult to achieve due to the following issues:

  • Pure Cryptosporidium spp DNA from clinical and environmental samples is difficult to obtain in large volumes due to shed oocysts being very limited.
  • Shed oocysts are difficult to effectively purify, are likely to be contaminated with genomic material from other species and generally don't yield enough DNA for study
  • Cryptosporidium spp genomic material being so limited represents a severe drain on lab resources, as expensive and time-consuming sequencing projects must be undertaken to ensure research can continue.

The group demonstrate that their set of 100,000 RNA baits called "CryptoCap_100k" (developed and validated in-house) has the ability to enrich Cryptosporidium spp DNA from a wide range of samples and scenarios which could address the aforementioned challenges and help the research community going forward.

Contact us to enquire about CryptoCap_100k

Daicel Arbor