Gene Delivery in Targeted Cancer Cells
Adeno-associated viruses (AAV) are key to delivering therapeutic genes to target cancer cells. With their ability to facilitate efficient and tissue-specific gene delivery, AAVs are driving advancements in oncology research, including oncolytic therapies and gene-modulating treatments. They have become essential tools for in vitro cancer studies and are being used for in-vivo preclinical cancer models. 68% of viral vectors have been used in gene therapy pre-clinical trials . For instance, in trials for familial lipoprotein lipase (LPL) deficiency, an AAV1-based vector encoding the gain-of-function variant LPLS447X resulted in persistent gene expression and protein activity, which led to sustained decreases in the incidence of pancreatitis.
2BScientific Limited offers a range of services and regents to efficiently perform and enhance your AAV technology. With the help of our supplier PROGEN who are experts in the field of gene delivery, they can offer variety of antibodies specific to different AAV serotypes, AAV Elisa kits and titration kits that are essential for quality control in gene therapy research
Progen provides variety of antibodies specific to different AAV serotypes. These antibodies are useful for characterising different stages of AAV infection and for applications like immunolocalization, immunoprecipitation, and western blot analysis:
- Offers AAV Detection Kits, like the Dip'n'Check kits which are quick and easy to use lateral flow assays for detecting intact AAV capsids for pre-testing. These kits are useful for estimating and comparing AAV concentrations in various samples for AAV1, AAV2, AAV3, AAV6, AAV8 and AAV9.
- The AAV Capsid Titer Elisa kits are industry gold standards that are essential to carry out quantification of rAAV capsid titers to ensure a safe gene transfer to the target cell.
- Unlike other suppliers Progen offers AAV Standards that have been a challenge for many due to lack of suitable AAV reference material. These characterised standards offer 100% reliability and ensure comparability of assays.
