Epigenetic Changes: Methyl Detection and Histone Antibodies
Epigenetic changes involve modifications to DNA and histones that affect gene expression without altering the DNA sequence. These changes include DNA methylation, histone modification, and non-coding RNA interactions. In cancer, epigenetic alterations can silence tumour suppressor genes or activate oncogenes, contributing to tumorigenesis. For example, hypermethylation of promoter regions in tumour suppressor genes can prevent their expression, allowing cancer cells to proliferate unchecked. Understanding these epigenetic mechanisms is vital for developing targeted therapies and diagnostic tools in oncology.
2BScientific Limited works closely with reputable suppliers to study Epigenetics changes. For epigenetic research, they offer products such as DNA methylation kits from Methyldetect. These tools enable researchers to explore the dynamic and complex nature of cellular regulations.
Cusabio
For Epigenetics Modifications, Cusabio offers a range of Histone Modification antibodies and Elisa Kits:
- Epigenetic assays that are specific such as DNA Methylation assay DNMT1 and DNMT3a
- Chromatin remodelling antibodies – for targeting changes in the chromatin structure
MethylDetect
MethylDetect provide reagents specifically focusing on DNA methylation to make the MS-HRM technology accessible to both new and experienced researchers in the field of epigenetics:
- EpiMelt Methylation Detection Assays: These ready-to-use kits are based on Methylation Sensitive High-Resolution Melting (MS-HRM) technology- offers locus specific detection and Bisulfite Modification Standard Kits: These kits offer high efficiency and reliability for converting unmethylated cytosines to uracil, which is a crucial step in methylation analysis – used together to achieve the methylation required.