Antibody Panels for Tumour Microenvironment (TME)
Tumour Microenvironment (TME):
TME is a complex and dynamic network of non-cancerous cells, blood vessels, extracellular matrix and plethora of immune cells that regulate the development of tumour environment. TME has a multitude of markers and pathways that serve to initiate progression, metastasis, recurrence and drug resistance. Understanding the surrounding TME are crucial for development of anti-cancer therapies and immunotherapy. Many suppliers have developed a range of TME related antibody panels and microarrays that can provide faster approach to understanding the antibody markers affecting the Tumour progression process.
2BScientific Limited in association with their trusted suppliers offer a range of TME biomarker antibody panels and microarrays that can shed light on the progression of the tumour cells in terms of Angiogenesis, Tumour Immune surveillance, and Cancer promoting immune cell detection are some of the ways to identify key targets to develop anti-cancer therapy.
Related Suppliers
Acro Biosystems
Acro Biosystems, through the help of Global Cancer Observatory (GCO), have identified specific TME targets by offering a range of recombinant proteins with Tags for TGF-β, Notch , Integrin, VEGF signalling pathways. Acro offers TGF-β and their subunit recombinant proteins that effectively induces the TME by activating and differentiating fibroblasts, MSCs and epithelial tumour cells. TGF-β suppresses tumour adaptive immunity mainly by inhibiting T cell activation, TGF-β promotes the expression of antigen-induced programmed cell death protein 1 (PD-1) in CD8 + T cells.
Arigo Bioscience
Arigo Bioscience offers a range of antibody panels for TME analysis:
- CAF Marker Antibody Panel (ARG30347) – Cancer Associated Fibroblasts are stromal cells that are predominantly found in TME to help with tumour progression and by recruiting immunosuppressive cells to accelerate cancer spread.
- Tumor-infiltrating Lymphocyte Antibody Panel (ARG30334) – relevant for Tumour immune surveillance that is predominantly mediated by CD8+ cytotoxic T lymphocytes (CTLs), natural killer cells (NK), neutrophils, and several subtypes of effector CD4+ T cells (CD4s).
Raybiotech
Raybiotech offers a plethora of Microarray services and products that can help understand cytokine responses to Tumorigenesis some of them include are:
- Human Angiogenesis Array - Range of Inflammation Array - Human MMP Arrays - Human Growth Factor Arrays.
- Also offers a range of Arrays that are specifically designed for the detection of Specific cancers Biomarkers especially for Human Gastric Cancer Biomarker Array , Human Cancer Biomarker Array, Lung Cancer IgA Autoantibody Array G1 and more.