AZDye 430 Picolyl Azide

Product Sizes

1 mg

CCT-1272-1MG

5 mg

CCT-1272-5MG

25 mg

CCT-1272-25MG

About this Product

SKU:: CCT-1272
Application:: Conjugation/Labeling
Conjugate:: AZDye™ 430
Extra Details:: AZDye™ 430 Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boost the efficiency of the CuAAC reaction, resulting in a faster and more biocompatible CuAAC labeling. Up to 40-fold increase of signal intensity, compared to conventional azides, was reported. In addition, the use picolyl azides instead of conventional azides allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling, significantly improving biocompatibility of CuAAC labeling protocol. In summary, the introduction of a copper-chelating motif into azide probe leads to a substantial increase in the sensitivity and reduced cell toxicity of CuAAC detection alkyne-tagged biomolecules. This will be of special value for the detection of low abundance targets or living system imaging. AZDye™ 430 is structurally identical to Alexa Fluor® 430. Its absorption/emission spectra is a perfect match to spectra of many other structurally similar dyes, including Alexa Fluor® 430 and CF®430 Dye.
Molecular Weight:: 705.71 (protonated)
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C desiccated. Avoid freeze/thaw cycles.
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores

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