GFP expressing RGD fiber modified Adenovirus (Ad(RGD)-CMV-GFP)
Product Sizes
200 ul
£654.00
1768-200UL
About this Product
- SKU:
- 1768
- Additional Names:
- Ad(RGD)-CMV-GFP|GFP expressing RGD fiber modified Adenovirus
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Concentration:
- 1E10 PFU/ml
- Extra Details:
- Ad infection is initiated by recognition of the native Ad5 receptor, coxsackievirus-adenovirus receptor (CAR), on target cells by the carboxy-terminal portion (i.e., knob) of the fiber protein. Therefore the infection efficiency of adenovirus is very low for cells with low or no CAR receptors. Arg-Gly-Asp (RGD) motif was introduced in the surface-exposed loops of adenovirus fiber knob, this enables the adenovirus to bypass CAR and mediate cell entry via RGD binding integrins. So the RDG modified adenovirus can be used for "retargeting" cells that regular adenovirus doesn't work well. The infection effeciency of RDG modified adenovirus can be tens or hundreds of times higher than standard Ad5 in some cells, including human or mouse macrophages, T cells, synoviocytes, islet grafts, adipocytes, MEF, etc.This is a RGD modified replication-deficient adenovirus expressing eGFP under a CMV promoter., vectorbiolabs
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Viral Particles
- Manufacturer's Data Sheet:1768-gfp-expressing-rgd-fiber-modified-adenovirus
