Phospholipase C, gamma 2 (phosphatidylinositol-specific) Adenovirus (Ad-PLCgamma2)
Product Sizes
200 ul
£882.00
1583-200UL
About this Product
- SKU:
- 1583
- Additional Names:
- Ad-PLCgamma2|Phospholipase C, gamma 2 (phosphatidylinositol-specific) Adenovirus
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Concentration:
- 1E10 PFU/ml
- Extra Details:
- Phospholipase C I³1 (PLC I³1), a phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2)-specific phosphodiesterase plays a critical role in the initiation of receptor-mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol-4,5-bisphosphate. A total of nine mammalian PLC isozymes have been described (PLC B Beta1, PLC B Beta2, PLC B Beta3, PLC B Beta4, PLC I³1, PLC I³2, PLC I'1, PLC D Delta2 and PLC Iu) with molecular weights ranging from 85 to 255 kDa. The I³-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two I³-type enzymes, but not the B Beta and I' isozymes, are subject to activation by a number of protein tyrosine kinases, which associate with SH2 domains and induce their activation by phosphorylation. In contrast, activation of PLC B Beta1, PLC B Beta2 and PLC I³3 is mediated by the I+/- subunits of the Gq class of heterotrimeric G proteins and by certain G protein B BetaI³ subunits. PLC-L (for PLC-deleted in lung carcinoma) plays a role in inositol phospholipid-based intracellular signaling and contributes to the progression of human lung carcinoma. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1) and C-gamma-2 (PLCG2) enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3., vectorbiolabs
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Viral Particles
- Manufacturer's Data Sheet:1583-phospholipase-c-gamma-2-phosphatidylinositol-specific-adenovirus
