Neuroblastoma RAS viral (v-ras) oncogene homolog Adenovirus (Ad-N-ras)
Product Sizes
200 ul
£882.00
1565-200UL
About this Product
- SKU:
- 1565
- Additional Names:
- Ad-N-ras|Neuroblastoma RAS viral (v-ras) oncogene homolog Adenovirus
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Concentration:
- 1E10 PFU/ml
- Extra Details:
- H-, K- and N-Ras genes encode 21 kDa guanine nucleotide-binding proteins. H-Ras and K-Ras were first identified as oncogenes of acutely transforming RNA tumor viruses. Subsequently, mutated Ras genes have been found in many human tumors, providing evidence for a common genetic target in cancer. Ras-encoded proteins bind to GDP and to GTP with high affinity and possess a low level of intrinsic GTPase activity that can be stimulated over 100-fold by interaction with cytosolic GTPase activating protein (GAP). M-Ras was identified as a GTPase that shares structural similarities to the Ras family proteins. In mammals, a variety of extracellular growth factors that act through protein tyrosine kinase receptors, such as insulin, platelet-derived growth factor and nerve growth factor, require Ras to exert their effects. Ras p21 in its active GTP bound state binds to Raf-1, resulting in activation of the MAP kinase signaling cascade. An additional member of the Ras family, Rheb (Ras-related GTP-binding protein), also interacts with Raf-1. This interaction is potentiated by growth factors and agents that increase cAMP levels. R-Ras and TC 21 (also designated R-Ras-2) are also members of the Ras family., vectorbiolabs
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Viral Particles
- Manufacturer's Data Sheet:1565-neuroblastoma-ras-viral-v-ras-oncogene-homolog-adenovirus
