Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Adenovirus (Ad-Id-1)
Product Sizes
200 ul
£882.00
1507-200UL
About this Product
- SKU:
- 1507
- Additional Names:
- Ad-Id-1|Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Adenovirus
- Buffer:
- DMEM, 2% BSA, 2.5% Glycerol
- Concentration:
- 1E10 PFU/ml
- Extra Details:
- Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and bHLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Id1 inhibits DNA binding of E12 and Myo D and inhibits muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, which allows E12 and/or E47 to form heterodimers with Myo D and myogenin to activate myogenic differentiation. Expression of each of the Id proteins is strongly dependent on growth factor activation. A reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed re-entry of arrested cells into the cell cycle following growth factor stimulation., vectorbiolabs
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Viral Particles
- Manufacturer's Data Sheet:1507-inhibitor-of-dna-binding-1-dominant-negative-helix-loop-helix-protein-adenovirus
