OATP2 (Organic Anion Transporting Polypeptide 2) (Not for Export EU)
Product Sizes
100ul
£704.00
O3001-10-100UL
About this Product
- SKU:
- O3001-10
- Clonality:
- Polyclonal
- Extra Details:
- Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called “renal secretion”. Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Oatp2 (also called OATP-B1; 661 aa; 12 TM), cloned from rat brain, shares significant homology with rat oatp1 and OAT-K1 (77%) and human OATP (73%). It is highly expressed in brain, liver, and kidney but not in heart, spleen, lung, muscle, and testes. Oatp2 mediates uptake of taurocholate, estrogen conjugates, and cardiac glycosides.. Unlike other oatp’s, oatp2 also transported digioxin. Applications: Suitable for use in ELISA. Although not tested, Western Blot may potentially be used as an application. Other applications not tested. Recommended Dilutions: ELISA: 1:10,000-50,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to 12aa near the C-terminus of rat OATP2, conjugated to KLH. Species Sequence Homology: mouse, 50%
- Isotype:
- IgG
- Physical State:
- Supplied as liquid in PBS, 0.05% sodium azide
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes rat OATP2. No significant sequence homology is detected with other OATP1 and OATP3 or human OATP or LST-1.
- Source:
- rat
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Polyclonal Antibody
