NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, PYRIN-containing APAF1-like Protein 2, Nucleotide-Binding Site Protein 1)
Product Sizes
100ug
£800.00
N0018-63D-100UG
About this Product
- SKU:
- N0018-63D
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- NALP2 (NAcht Leucine-rich repeat Protein 2, also known as PAN1) is a cytosolic, 121kD member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NFkappaB, it suppresses TNF-alpha production in response to LPS; via procaspase-1, it promotes proIL-1Beta cleavage and release. Human NALP2 is 1062 amino acids (aa) in length. It contains an N-terminal Pyrin domain (aa 9-90), followed by a Nacht region and nine LRRs (aa 467-1033). Four alternate isoforms exist. Three show deletions of aa’s 109-132, 133-154 and 847-1062, respectively; a fourth shows a 38 aa substitution for aa’s 1-903. No close rodent counterparts have been reported. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1.0ug/ml. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Sheep
- Immunogen:
- E. coli-derived recombinant human NALP2. (aa 1 - 208)
- Isotype:
- IgG
- Physical State:
- Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 100ul sterile 40-50% glycerol, PBS 0.02% sodium azide.
- Purity:
- Purified by immunoaffinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human NALP2.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
