Metal Transporter Protein (MTP1) (Not for Export EU)
Product Sizes
100ul
£704.00
M4695-50-100UL
About this Product
- SKU:
- M4695-50
- Clonality:
- Polyclonal
- Extra Details:
- A novel iron-regulated gene that is homologous to the DMAT1, termed Metal Transporter Protein (MTP1, human 571aa, mouse 570aa; ~90% similarity), has been identified. MTP1 is also described as iron-regulated transporter (IREG1), Ferroportin1 and SLC11A3 iron transporter or solute carrier family 11 (proton coupled divalent metal ion transporter), Member 3, formerly SLC11A3). MTP1 contains IRE in the 5’-UTR. It is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial system, the duodenum and the pregnant uterus. MTP1 is also expressed in muscle and central nervous system cells in the embryo. In the adult mouse, MTP1 expression in the liver and duodenum are reciprocally regulated. Iron deficiency induces MTP1 expression in the duodenum but down-regulates expression in the liver. Therefore, MTP1 appears to be an iron-regulated protein that is involved in iron metabolism. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000-1:5000 (ECL) ELISA: 1:10,000-1: 50,000. Coat with 1ug/ml Control Peptide. Optimal dilutions to be determined by the researcher. Recommended Control Peptide: M4695-50A: Metal Transporter Protein, Mouse, Control Peptide (MTP1) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to19aa within the predicted cytoplasmic C-terminus of mouse MTP1 conjugated to KLH. Species Sequence Homology: mouse ferroprotein1/IREG1,100%; rat ferroprotein 1, 90%; human, chimp IREG1/ferroprotein1, 78%; rabbit MTP1/REG1/ ferroprotein1, 73%.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, 0.05% sodium azide.
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse Metal Transporter Protein. Does not distinguish between isoforms ferroprotein1/IREG1, ferroprotein 1 and IRG1/ferroprotein1.
- Source:
- mouse
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Polyclonal Antibody
