LYVE-1 (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor, LYVE1, CRSBP1, Extracellular Link Domain Containing 1, Hyaluronic Acid Receptor, HAR, Lymphatic Endothelium Specific Hyaluronan Receptor, Lymphatic Vessel Endothelial Hyaluronan Receptor 1, XLKD1)
Product Sizes
500ug
£1029.00
L9375-01A-500UG
About this Product
- SKU:
- L9375-01A
- translate.label.attr.clone:
- 9j8
- Clonality:
- Monoclonal
- Extra Details:
- LYVE-1, also named extracellular link domain containing 1, is a 60-70kD type I transmembrane protein that functions as a receptor for both soluble and immobilized hyaluronan (HA). It shares 41% aa sequence homology with CD44, another known receptor for HA. LYVE-1 expression is mostly restricted to lymphatic vessels. LYVE-1 is a useful molecular marker for lymphatic endothelial cells. Applications: Suitable for use in Direct ELISA and Blocking of receptor-ligand interaction. Other applications not tested. Recommended Dilutions: Blocking of receptor-ligand interaction: 0.04-0.2ug/ml will block 50% binding of 1.5ug/ml of biotinylated Hyaluronan to immobilized rhLYVE-1 coated at 5ug/ml. At 2ug/ml, it will block >90%. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Ser24-Thr238 of human LYVE-1, exprssed in NS0 cells.
- Isotype:
- IgG1
- Physical State:
- Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 1ml sterile PBS.
- Purity:
- Purified by Protein G affinity chromatography from hybridoma culture supernatant. Endotoxin: ≤0.1EU/ug (LAL)
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human LYVE-1.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Monoclonal Antibody
