LBH-589 (Panobinostat, NVP-LBH589)
Product Sizes
10mg
£368.00
L1535-10MG
About this Product
- SKU:
- L1535
- CAS Number:
- 404950-80-7
- Extra Details:
- Panobinostat, a histone deacetylase inhibitor, is being tested in humans against cutaneous T cell lymphoma, prostate cancer, myelodysplastic syndromes, breast cancer, chronic myelogenous leukemia, and other types of malignant disease. Panobinostat inhibited histone deacetylase and induced acetylation of histone H3 and alpha-tubulin protein in human umbilical vein endothelial cells (HUVEC), which resulted in induction of G(2)-M cell cycle arrest and inhibition of HUVEC proliferation and viability. Panobinostat at noncytotoxic concentrations inhibited endothelial tube formation, Matrigel invasion, AKT activity, extracellular signal-regulated kinase 1/2 phosphorylation and chemokine receptor CXCR4 expression. It aslo reduced angiogenesis and PC-3 tumor growth in mice. Synonyms: (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide; LBH 589; LBH-589 CAS No: 404950-80-7 Molecular Formula: C₂₁H₂₃N₃O₂ Molecular Weight: 349.43 Appearance: Off-white to light brown powder Purity: ≥98% Method for Determining Identity: 1H-NMR Spectroscopic Analysis Storage and Stability: Store at -20ºC. Stable for 6 months after receipt.
- Molecular Weight:
- 349.43
- Physical State:
- White to off-white powder
- Purity:
- ≥98%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Enzymes
