Interleukin 17 Receptor (IL-17R, IL-17RA)
Product Sizes
500ug
£1029.00
I8439-35-500UG
About this Product
- SKU:
- I8439-35
- Application:
- Western Blot
- translate.label.attr.clone:
- 7H43
- Clonality:
- Monoclonal
- Extra Details:
- IL-17R, also known as IL-17RA, is a widely expressed 120kD glycosylated type I protein that plays a central role in inflammatory responses. IL-17R associates with IL-17RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17R ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines. Within the ECD, human IL-17R shares 72% aa sequence identity with mouse and rat IL-17R. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilution: ELISA (Capture): 2-8ug/ml. Western Blot: 1-2ug/ml. Using a colorimetric detection system, the detection limit is ~5ng/lane under non-reducing and reducing conditions. Chemiluminescent detection will increase sensitivity by 5 to 50 fold. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to Leu33-Trp320 from human Interleukin 17 receptor, expressed in NS0 cells.
- Isotype:
- IgG2b
- Physical State:
- Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
- Purity:
- Purified by Protein G affinity chromatography from hybridoma culture supernatant.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human IL-17R.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Monoclonal Antibody
