Histamine Receptor 1 (H1R) (Not for Export EU)
Product Sizes
100ul
£704.00
H5090-01C-100UL
About this Product
- SKU:
- H5090-01C
- Clonality:
- Polyclonal
- Extra Details:
- Histamine, one of the most important mediators of allergy and inflammation, is a chemical messenger and aminergic neurotransmitters. It plays an important role in a multitude of physiological processes in central and peripheral tissues. Histamine is synthesized in a restricted population of neurons located in the tuberomammillary nucleus of the posterior hypothalamus implicated in many brain functions (e.g. sleep/wakefulness, hormonal secretion, cardiovascular control, thermoregulation, food intake, and memory formation). In peripheral tissues histamine is stored in mast cells, basophils, enterochromaffin cells. Histamine release leads to various well-known symptoms of allergic conditions in the skin and the airway system. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 using ECL. ELISA: 1:10,000-1:100,000 (Coat with 50-100ng of control peptide (H5090-01B)/well). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- A 17 aa peptide near the cytoplasmic, C-terminus of rat H1R (KLH).
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid, 0.05% sodium azide.
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes rat histamine 1 receptor 1. No significant sequence homology exists with other histamine receptors. Species sequence homology: mouse and bovine; 100%, 94%; human, fish and monkey and 80%; guinea pig
- Source:
- rat
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
