GLUT 12 (Glucose Transporter) (Not for Export EU)
Product Sizes
100ul
£704.00
G3900-97A-100UL
About this Product
- SKU:
- G3900-97A
- Clonality:
- Polyclonal
- Extra Details:
- Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (GLUT-1 to GLUT-7, MW 40-60kD) and Sodium glucose co-transporter-1 (SGLT-1: 662aa, ~75kD). Individual members of this family have identical predicted secondary structures with 12 transmembrane domains. Both N- and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting. GLUT isoform differ in their tissue expression, substrate specificity and kinetic characteristics. GLUT-12 (human 617aa, monkey 621aa, ~ 50kD; ~30% homology with GLUT-4 and 40% with GLUT-10) is expressed in skeletal muscle, adipose tissue, and small intestine. Applications: Suitable for use in ELISA. Western Blot, though not tested, may potentially be used as an application. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000-1:5000 (ECL). ELISA: 1:10,000-1:50,000 Optimal dilutions to be determined by the researcher. Recommended Control Peptide: G3900-97: GLUT 12, Human, Control Peptide (Glucose Transporter) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide consisting of 15aa sequence near the cytoplasmic, C-terminus of human Glut-12 (KLH). Species Sequence Homology: monkey: 100%; mouse: 71%; rat: 69%.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, 0.05% sodium azide.
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human GLUT 12. No significant sequence homology with other GLUTs.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Polyclonal Antibody
