Glucose Regulated Protein, NT, 75kD (Grp 75) (Not for Export EU)
Product Sizes
200ul
£570.00
G3057-12-200UL
About this Product
- SKU:
- G3057-12
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle. Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53. Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts. And finally, like its E.coli homolog DnaK, GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 using ECL at 1-2 minute exposure. Optimum dilutions to be determined by researcher. Secondary Antibody: Rabbit IgG (HRP) diluted at 1:100,000 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- N-terminal fragment of human Grp 75 (aa47-69)
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid.
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human Glucose Regulated Protein 75. Species Crossreactivity: mouse
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
