CCR1 (Chemokine Receptor 1, CC-CCR-1) (PE)
Product Sizes
100Tests
£806.00
C2100-16E-100TESTS
About this Product
- SKU:
- C2100-16E
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- 11D87
- Clonality:
- Monoclonal
- Extra Details:
- CCR1 (C-C chemokine receptor 1; also known as MIP-1a receptor and CD191) is a 43kD member of the G protein-coupled receptor 1 family of transmembrane proteins. Mouse CCR1 is expressed on osteoclasts, IL-13+ T cells, neutrophils, bone marrow-derived mast cells, eosinophils, monocytes, and vascular intimal smooth muscle cells. Multiple chemokines are reported to bind to CCR1. MIP-1a /CCL3 and RANTES/CCL5 are natural ligands, while CCL15, CCL9 and CCL23 are potent agonists after N-terminal processing. Mouse CCR1 is a seven transmembrane protein that is 355aa in length. It contains a 34aa N-terminal extracellular domain plus a 50aa C-terminal cytoplasmic tail. Over aa sequences 1-34, 92-107, 172-192 and 265-281 collectively, mouse CCR1 shares 76% and 89% aa identity with human and rat CCRI respectively. Applications: Suitable for use Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul per 10e6 cells Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with B cells from Balb/c mice. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
- Host:
- Rat
- Immunogen:
- E. coli-derived recombinant mouse CCR1. Extracellular regions (aa1-34, aa92-107, aa172-192, aa 65-281); UniProt # P51675
- Isotype:
- IgG2b
- Physical State:
- Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
- Purity:
- Purified by Protein G affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse CCR1.
- Source:
- mouse
- Storage Conditions:
- 4[o]C Do Not Freeze
- Supplier:
- United States Biological
- Type:
- Antibodies:Monoclonal Antibody
