ABIN-2 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation)
Product Sizes
100ug
£537.00
A0004-75-100UG
About this Product
- SKU:
- A0004-75
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- ABIN-2 binds to the COOH-terminal zinc finger domain of A20. NF-kB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation (ABIN-2) binds to A-20. ABIN-2 interferes with NF-kB activation upstream of the IKK complex and might contribute to NF-kB inhibitory function of A-20. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 2-4ug/ml Optimal dilutions to be determined by the researcher. Recommended Positive Control: Mouse heart or lung lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptides corresponding to human ABIN-2
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide
- Purity:
- Purified by Protein G affinity chromatography
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human ABIN-2. Species Crossreactivity: mouse and rat
- Source:
- human
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Polyclonal Antibody
