TFPI (Tissue Factor Pathway Inhibitor, TFI, EPI, LACI, TFPI1, Lipoprotein-Associated Coagulation Inhibitor, Extrinsic pathway inhibitor)
Product Sizes
200ul
£466.00
365262-200UL
About this Product
- SKU:
- 365262
- Application:
- Western Blot
- Clonality:
- Polyclonal
- Extra Details:
- Tissue Factor Pathway Inhibitor (TFPI) circulates in plasma as a complex with LDL>HDL>>VLDV. In plasma, TFPI is found in several forms: one at 36,000kD, one at 43,000kD, and the various truncated forms. This size heterogeneity appears in part to be the result of the formation of mixed disulfide complexes between TFPI and apolipoprotein AII. Approximately 10% of total TFPI is carried by platelets, which release TFPI once they are activated by thrombin. Thus, at the site of a wound, where platelets aggregate, elevated levels of TFPI are present. TFPI has dual inhibitory function (against factor Xa and factor VIIa/TF). This is consistent with the presence of multiple Kunitz-type domains: (Kunitz for factor VIIa/TF and Kunitz for factor Xa interaction). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.01-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa29-251 of human TFPI, expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in 0.01M PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human TFPI. Species Crossreactivity: rat
- Source:
- human
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies:Polyclonal Antibody
