PAK1 (p21 Protein Activated Kinase 1, PAKalpha, p65-PAK, p21/Cdc42/Rac1-Activated Kinase 1, Serine/threonine-protein kinase PAK 1)
Product Sizes
200ul
£626.00
364514-200UL
About this Product
- SKU:
- 364514
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. PAK1 is a member of a family of serine/threonine kinases related to yeast Ste20. The human PAK1 gene encodes a 545aa polypeptide that is 98% identical to rat PAK1 and 52% identical to yeast Ste20. Activity of PAK1 is induced by coexpression with RAC1 or CDC42. PAK is believed to act directly on the JNK1 MAP kinase pathway. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa252-501 of human PAK1, expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in 0.01M PBS, pH7.4, 0.05% Proclin-300, 50% glycerol.
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human PAK1.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
