NRG4 (Neuregulin 4, HRG4, Pro-NRG4, Pro-neuregulin-4, membrane-bound isoform)
Product Sizes
200ul
£626.00
364421-200UL
About this Product
- SKU:
- 364421
- Application:
- Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. By searching databases for sequences similar to NRG1, Harari et al. (1999) identified an Nrg4 EST clone originating from a mouse liver cDNA library. The deduced 115aa protein has a putative N-terminal EGF-like extracellular domain with 2 N-glycosylation sites, followed by a transmembrane region, and a short C-terminal cytoplasmic tail with another N-glycosylation site. It also has 6 cysteines predicted to form 3 disulfide bridges within the extracellular domain. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa1-62 of human NRG4, expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human NRG4.
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
