NOSTRIN (Nitric Oxide Synthase Trafficker, BM247 homolog, Nitric oxide synthase traffic inducer, eNOS-trafficking inducer)
Product Sizes
200ul
£581.00
364393-200UL
About this Product
- SKU:
- 364393
- Application:
- Immunohistochemistry, Immunofluorescence
- Clonality:
- Polyclonal
- Extra Details:
- Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production. NOSTRIN overexpression induced a redistribution of ENOS from the plasma membrane to vesicle-like structures matching the NOSTRIN localization pattern and, at the same time, led to significant inhibition of NO release. Deletion of the CDC15 domain of NOSTRIN disrupted the subcellular distribution of both NOSTRIN and ENOS in these cells. Applications: Suitable for use in Immunohistochemistry, Immunocytochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-20ug/ml Immunocytochemistry/Immunofluorescence: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa6-245 of mouse NOSTRIN, expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse NOSTRIN. Species Crossreactivity: human
- Source:
- mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
