LSR (Lipolysis Stimulated Lipoprotein Receptor, LISCH7, ILDR3, LISCH, Lipolysis-Stimulated Remnant, Immunoglobulin-Like Domain Containing Receptor 3)
Product Sizes
200ul
£473.00
364018-200UL
About this Product
- SKU:
- 364018
- Application:
- Western Blot, Immunofluorescence
- Clonality:
- Polyclonal
- Extra Details:
- LSR is a multimeric protein complex in the liver that undergoes conformational changes upon binding of free fatty acids, thereby revealing a binding site (s) that recognizes both apoB and apoE. Complete inactivation of the LSR gene is embryonic lethal in mice. LSR cooperates with the LDL receptor in the final hepatic processing of apoB-containing lipoproteins and represents a novel therapeutic target for the treatment of hyperlipidemia associated with obesity and atherosclerosis. The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids. Antibodies inhibiting LSR functions showed that the receptor is a heterotrimer or tetramer consisting of 68kD (alpha) and 56kD (beta) subunits associated through disulfide bridges. Applications: Suitable for use in Western Blot and Immunocytochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 0.01-3ug/ml Immunofluorescence (IC): 5-30ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa35-205 of mouse LSR, expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, pH 7.4, 0.05% Proclin-300, 50% glycerol.
- Purity:
- Purified by immunoaffinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse LSR. Species Crossreactivity: human and rat
- Source:
- mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
