ITGa2 (Integrin Alpha 2, CD49b, BR, GPIa, VLA-2, VLAA2, Platelet membrane glycoprotein Ia, Alpha 2 Subunit Of VLA-2 Receptor, Very Late Activation Proteins 2 Receptor, Collagen receptor, VLA-2 alpha)
Product Sizes
200ul
£544.00
363775-200UL
About this Product
- SKU:
- 363775
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- The CD49b protein is an integrin alpha subunit. It makes up half of the alpha2 beta1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. Kunicki et al. (1997) identified 2 silent, linked polymorphisms, 807C-T and 873G-A, within the coding region of the ITGA2 gene that are associated with GP Ia/IIa surface expression, i.e., the number of GP Ia/IIa copies on the platelet membrane. High surface expression was found in platelets derived from 807T homozygotes, whereas low surface expression was found in platelets from 807C homozygotes. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.01-2ug/ml Immunohistochemistry (paraffin): 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein corresponding to aa212-370 of mouse ITGa2 expressed in E. coli.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Purity:
- Purified by Protein A and peptide affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse ITGa2. Species Crossreactivity: human
- Source:
- mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
