A 83-01
Product Sizes
5mg
£320.00
254482-5MG
About this Product
- SKU:
- 254482
- CAS Number:
- 909910-43-6
- Extra Details:
- A 83-01 is a selective inhibitor of TGF-b type I receptor. A 83-01 treatment increases tumor permeability. A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5nM, respectively).1 It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. It has little effect on bone morphogenic type I receptors, p38 mitogen-activated protein kinase, or ERK.1 A 83-01 has been used to reprogram fibroblasts into alternative lineages, including neural stem cells and cardiomyocytes. Synonyms: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; TGF-β RI Kinase Inhibitor IV; Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV; 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole; ALK5 Inhibitor IV CAS No: 909910-43-6 Molecular Formula: C₂₅H₁₉N₅S Molecular Weight: 421.52 Appearance: Off-white to pale yellow powder Purity (HPLC): ≥95% Melting Point: 207-209°C Method for Determining Identity: Proton NMR Spectroscopic Analysis and Mass Spectrum Analysis λmax: 227, 307nm Solubility: Ethanol: 0.3mg/ml; DMSO: 14mg/ml; DMF: 25mg/ml; DMSO:PBS (pH 7.2) (1:2): (0.3mg/ml) Storage and Stabillity: Store at -20°C under inert atmosphere. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Molecular Weight:
- 421.52
- Physical State:
- Off-white to pale yellow powder
- Purity:
- ≥95%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 4[o]C
- Type:
- Buffers & General Consumables:Others
