OAT1 (Solute Carrier Family 22 Member 6, Organic Anion Transporter 1, hOAT1, PAH Transporter, hPAHT, Renal Organic Anion Transporter 1, hROAT1, SLC22A6, OAT1, PAHT)
Product Sizes
100ul
£863.00
224673-100UL
About this Product
- SKU:
- 224673
- Application:
- Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- OAT1 (organic anion transporter 1), a 563 amino acid protein, and OAT3 (organic anion transporter 3), a 542 amino acid protein, are two members of the OAT family and are highly expressed in kidneys. Localized specifically to the basolateral membrane, OAT1 and OAT3 are involved in the elimination of toxic organic anions, such as benzylpenicillin and cimetidine, from proximal renal tubules. Via their ability to remove anions from renal tissues, OAT1 and OAT3 are able to regulate the amount of toxins within the kidneys. Additionally, OAT1 functions as an organic anion exchanger that couples the uptake of one organic anion molecule with the efflux of one endogenous dicarboxylic acid molecule, such as ketoglutarate. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to amino acids 271-320 of human OAT1. Swiss/UniProt Accession #: O95742
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid PBS, pH 7.2, 15mM sodium azide.
- Purity:
- Purified by immunoaffinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes endogenous levels of human OAT1. Species Crossreactivity: mouse and rat
- Source:
- human
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
