Fas (CD95, APO-1, TNFRSF6, Tumor Necrosis Factor Receptor Superfamily Member 6, Apoptosis-mediating Surface Antigen FAS) (Preservative Free)
Product Sizes
50ug
£412.00
207169-50UG
About this Product
- SKU:
- 207169
- Application:
- Immunoprecipitation, Flow Cytometry, Western Blot, Apoptosis
- translate.label.attr.clone:
- APO-1-3
- Clonality:
- Monoclonal
- Extra Details:
- Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Funtional Applications. Other applications not tested. Recommended Dilution: Fuctional Application: Induces apoptosis with or without cross-linking (Protein A), depending on cell type. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to human Fas.
- Isotype:
- IgG3
- Physical State:
- Supplied as a liquid in PBS. No preservative added.
- Purity:
- Purified from concentrated hybridoma tissue culture supernatant.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes human Fas.
- Source:
- human
- Storage Conditions:
- 4[o]C Do Not Freeze
- Type:
- Antibodies:Monoclonal Antibody
