RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand, TNF-related Activation-induced Cytokine, CD254, RANK L,, TNFSF11) (Biotin)
Product Sizes
100ul
£735.00
059448-100UL
About this Product
- SKU:
- 059448
- Application:
- Flow Cytometry, Immunohistochemistry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- 12A380
- Clonality:
- Monoclonal
- Extra Details:
- TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. TRANCE/RANKL is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunocytochemistry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: frozen and paraffin Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Mouse
- Immunogen:
- Bacterially expressed fusion protein containing amino acid residues 1-317 of mouse TRANCE.
- Isotype:
- IgG1,k
- Physical State:
- Supplied as a liquid in PBS, 0.05% sodium azide. Labeled with Biotin.
- Purity:
- Purified by Protein G affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes mouse RANKL. Species Crossreactivity: human
- Source:
- mouse
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Monoclonal Antibody
