Ricin A Chain
Product Sizes
100ug
£780.00
052675-100UG
About this Product
- SKU:
- 052675
- translate.label.attr.clone:
- RAC18
- Clonality:
- Monoclonal
- Extra Details:
- Ricin is a dimeric toxin derived from Ricinus communis (Caster bean). It is composed of a sugar-binding subunit (B chain) that attached to cell surface receptors and facilitate the entry of toxin into the target cell and a second subunit (A chain), whcih has glycosidase activity that inactivates ribosomes by depurinating a single adenosine residue from an exposed loop of the 28S ribosomal RNA. This leads to inhibition of protein synthesis in cells. The toxic effects of Ricin are attributed to the A chain. 052675 displays high avidity for intact ricin and inhibits its activity without affecting binding of ricin to cells. Immunization is shown to offer significant protection against ricin toxicity. Applications: Suitable for use in Indirect ELISA, Inhibition assays and Neutralization. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Mouse
- Immunogen:
- Purified Ricin A chain.
- Isotype:
- IgG2a,k
- Physical State:
- Supplied as a liquid in PBS. No preservative added.
- Purity:
- Purified by Protein G affinity chromatography.
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes Ricin A chain.
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Monoclonal Antibody
