Fractin (Not for Export EU)
Product Sizes
100ul
£614.00
046165-100UL
About this Product
- SKU:
- 046165
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer’s disease (Yang et al., 1998). It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press). Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry: 1:50-1:1000 Immunocytochemistry: 1:100-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to amino acid residues from the C-terminal region of the 32kD actin fragment.
- Isotype:
- IgG
- Physical State:
- Supplied as a liquid. No preservative added.
- Purity:
- Serum
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes endogenous levels of the ~32kD fractin protein. Shows no reactivity toward intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases. Detects the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease in Immunohistochemistry. Species Crossreactivity: h
- Storage Conditions:
- -20[o]C
- Supplier:
- United States Biological
- Type:
- Antibodies:Polyclonal Antibody
