ITCH

Product Sizes

50 ug

£517.00

K1400-50UG

About this Product

SKU:: K1400
Buffer:: 20 mM Tris, 150 mM NaCl, 2 mM BME, 10% Glycerol
Extra Details:: ITCH, also called atrophin-1 interacting protein 4 (AIP4), is a HECT-type E3 ubiquitin ligase. It contains an N-terminal Ca-dependent phospholipid-binding C2 domain, four WW domains, and a C-terminal HECT domain. Mice deficient in ITCH protein display many autoimmune-like disease characteristics such as lymphoproliferation in the spleen and lymph nodes. More than a dozen of substrates of ITCH have been identified including p63, p73 and Notch1. The ligase may be responsible for ubiquitinating proteins with K29-, K48-, and/or K63-linked ubiquitin chains.
Molecular Weight:: 102.8 kDa
Shipping Conditions:: Dry Ice
Source:: E. coli recombinant
Storage Conditions:: - 80 0C
Supplier:: UBP Bio
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules

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