ML323
Product Sizes
5 mg
£168.00
F4120-5MG
About this Product
- SKU:
- F4120
- Buffer:
- Powder; no buffer
- Extra Details:
- ML323 is a cell permealbe, selective and highly potent inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. ML 323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting USP1-UAF1. ML323 was used at 10-30 µM in various in vitro assay.
- Molecular Weight:
- 384.48 g/mol
- Shipping Conditions:
- Ambient
- Source:
- chemical synthesis
- Storage Conditions:
- -20 0C
- Supplier:
- UBP Bio
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
