Human Recombinant Alpha Synuclein (1-114) Monomers (C-terminal Truncated)
Product Sizes
100 ug
£484.00
SPR-536-100UG
2 x 100 ug
£812.00
SPR-536-2X100UG
5 x 100 ug
£1615.00
SPR-536-5X100UG
About this Product
- SKU:
- SPR-536
- Additional Names:
- A Alpha-Synuclein (1-114), Alpha Synuclein 1-114 Truncated, C-Terminally Truncated Alpha-Synuclein, Alpha-Synuclein Fragment (1-114), SNCA (1-114) Monomeric Protein, SNCA (1-114) Protein, Alpha-Synuclein Fragment 1-114
- Application:
- Cell-based/Functional Assay
- Buffer:
- PBS
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Concentration:
- 2 mg/ml
- Extra Details:
- Human recombinant alpha-synuclein (1-114) is a C-terminally truncated form of A Alpha-synuclein lacking residues 115-140. C-terminal truncation is a pathological modification observed in synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, and has been associated with increased aggregation and fibril formation relative to the full-length protein. Cleavage at residue Glu114 has been identified as a major physiological processing event of A Alpha-synuclein aggregates, and the resulting 1-114 species has been detected in disease-associated inclusions. Studies suggest that truncation of the C-terminal region alters A Alpha-synuclein conformation and promotes the formation of aggregation-prone species that may contribute to the development and progression of A Alpha-synuclein pathology. StressMarq's Alpha Synuclein (1-114) Monomers (C-Term Truncated) have been demonstrated to readily self-assemble in an in-vitro Thioflavin T seeding assay.
- Molecular Weight:
- 11.46 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILE
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/alpha-synuclein-1-114-monomers-c-term-truncated-spr-536/
