TDP-43 Hexamutant (W to S) Monomers
Product Sizes
100 ug
£547.00
SPR-522-100UG
2 x 100 ug
£927.00
SPR-522-2X100UG
5 x 100 ug
£1851.00
SPR-522-5X100UG
About this Product
- SKU:
- SPR-522
- Additional Names:
- TDP-43, TDP43, TARDBP, TAR DNA-binding protein 43, Transactive response DNA-binding protein 43, ALS10, TDP43_N domain-containing protein, TADBP_HUMAN, TADBP_MOUSE, TADBP_PONAB, TADBP_XENTR, TADBP_CHICK, TBPH, dmTDP43, dtar, dTBPH, dTDP, dTDP-43, tbph, TDPH, CG10327, Dmel_CG10327
- Application:
- Western Blot
- Buffer:
- 30mM Tris pH 7.4, 100 mM NaCl
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Concentration:
- 1 mg/ml
- Extra Details:
- TAR DNA-binding protein 43 (TDP-43) is a ubiquitously expressed RNA/DNA-binding protein that plays a pivotal role in RNA processing, including RNA splicing, mRNA turnover, and microRNA biogenesis. Its pathological mislocalization from the nucleus to the cytoplasm, accompanied by aggregation and post-translational modifications, is a hallmark of several neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer's disease. These TDP-43 proteinopathies disrupt nucleocytoplasmic transport and mitochondrial function, contributing to neuronal dysfunction and death. Recent studies have also highlighted TDP-43's involvement in DNA repair and chromatin remodeling, expanding its relevance in neurobiology beyond RNA processing. Notably, Pokrishevsky et al. (2024) demonstrated that when all six tryptophans are mutated to serines (trpless), this significantly reduces the protein's ability to cross-seed SOD1 aggregation. StressMarq's TDP-43 hexamutant monomers has shown a reduced propensity to aggregate.
- Immunogen:
- TDP-43 Hexamutant Monomers
- Molecular Weight:
- 44.61 kDa
- Purity:
- > 95% by A260/A280
- Purification:
- Affinity Purified
- Sequence:
- SEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGSGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPSKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRSCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSSGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGSGSASNAGSGSGFNGGFGSSMDSKSSGSGM
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/tdp-43-hexamutant-w→s-monomers-spr-522/
