Tau-441 (2N4R) Wild-Type Monomers
Product Sizes
100 ug
SPR-479-100UG
2 x 100 ug
SPR-479-2X100UG
5 x 100 ug
SPR-479-5X100UG
About this Product
- SKU:
- SPR-479
- Additional Names:
- MAPT, Tau, Tau-441, 2N4R, Tau40, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, microtubule-associated Tau, tubulin-associated unit, Paired Helical Filament-Tau, Phf-Tau, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- 10 mM HEPES, 100 mM NaCl pH 7.4
- CE/IVD:
- RUO
- Concentration:
- 2 mg/ml
- Extra Details:
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein essential for stabilizing neuronal microtubules and maintaining axonal transport. The Tau-441 isoform (2N4R), the longest variant expressed in the adult human brain, contains two N-terminal inserts and four microtubule-binding repeats, making it a key reference in tauopathy research. In its wild-type monomeric form, Tau-441 exhibits native folding and functional microtubule-binding capacity. This form serves as a critical baseline for understanding how mutations, post-translational modifications, and environmental stressors disrupt Tau's structure and function, leading to pathological aggregation. Studying wild-type monomers allows researchers to pinpoint the earliest molecular events that precede fibril formation and neurodegeneration. Tau-441 wild-type monomers are widely used in biochemical, structural, and cellular assays to investigate Tau's physiological roles and its transition into disease-associated conformers. These studies inform the development of therapeutic strategies aimed at preserving Tau's native state, preventing misfolding, and maintaining neuronal health. As a foundational model, Tau-441 wild-type monomers provide essential insights into Tau biology and offer a reference framework for evaluating the impact of disease-linked variants in neurodegenerative research.
- Immunogen:
- Tau-441 (2N4R) Monomers
- Molecular Weight:
- ~45.85 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/tau-protein-spr-479/
