Tau-441 (2N4R) P301S Mutant Monomers (Baculovirus/Sf9)
Product Sizes
100 ug
SPR-473-100UG
2 x 100 ug
SPR-473-2X100UG
5 x 100 ug
SPR-473-5X100UG
About this Product
- SKU:
- SPR-473
- Additional Names:
- Tau-441, Tau-F, Tau 441, 2N4R, MAPT, TAU, MTBT1, MTBT2, MAPTL, PPND, PPP1R103, FTDP-17, PHF-Tau, Paired Helical Filament-Tau, Neurofibrillary Tangle, NFTs, intracellular neurofibrillary tangles, Tau aggregates, Tau inclusions, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Concentration:
- 2 mg/ml
- Extra Details:
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein critical for maintaining neuronal architecture and intracellular transport. The Tau-441 isoform (2N4R), the longest adult brain variant, includes two N-terminal inserts and four microtubule-binding repeats, making it highly relevant in the context of tauopathies. The P301S mutation, located within the microtubule-binding domain, alters Tau's conformation and increases its tendency to misfold. While aggregated forms such as fibrils are well-known contributors to neurodegeneration, recent research highlights the importance of monomeric P301S Tau in initiating pathological cascades. These monomers exhibit altered biochemical properties, including reduced microtubule binding and increased susceptibility to post-translational modifications, which can prime them for aggregation and toxicity. Tau-441 P301S mutant monomers serve as a critical starting point for in vitro and in vivo studies exploring early-stage Tau dysfunction. Their use enables researchers to dissect the molecular events leading to aggregation, synaptic impairment, and neuronal death. These monomers also provide a baseline for evaluating therapeutic agents aimed at stabilizing native Tau, preventing misfolding, and interrupting disease progression before fibril formation. By modeling the earliest phases of Tau pathology, Tau-441 P301S mutant monomers offer a high-resolution lens into the mechanisms of neurodegenerative disease and support the development of preventative strategies in tauopathy research.
- Immunogen:
- Tau-441 (2N4R) P301S Monomers
- Molecular Weight:
- ~45.8 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHVSGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/tau-protein-spr-473/
