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Proteins and Peptides

Tau Truncated Fragment (AA297-391) (dGAE) Pre-formed Fibrils

Product Sizes
100 ug
SPR-461-100UG
2 x 100 ug
SPR-461-2X100UG
5 x 100 ug
SPR-461-5X100UG
About this Product
SKU:
SPR-461
Additional Names:
Tau dGAE, Tau 297-391, Truncated Tau, Tau fragment 297-391, microtubule-associated tau, MAPT, MAP, Tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, Tau PFFs
Application:
Cell-based/Functional Assay, SDS-PAGE, Western Blot
Buffer:
10mM PB pH7.4, 10mM DTT
CE/IVD:
RUO
Concentration:
2 mg/ml
Extra Details:
Tau protein, encoded by the MAPT gene (UniProt ID: P10636), plays a pivotal role in stabilizing neuronal microtubules and maintaining axonal integrity. In neurodegenerative disorders such as Alzheimer's disease and frontotemporal dementia, Tau undergoes pathological misfolding and aggregation into insoluble fibrils, forming neurofibrillary tangles-a hallmark of tauopathies. The dGAE fragment of Tau (residues 297-391) encompasses the core region of the protein's microtubule-binding domain and is intrinsically prone to self-assembly into B Beta-sheet-rich fibrillar structures. Pre-formed fibrils (PFFs) derived from Tau dGAE serve as a robust and reproducible model for studying the molecular mechanisms of Tau aggregation, seeding, and propagation in vitro and in vivo. These fibrils mimic the structural and biochemical properties of pathological Tau aggregates observed in human brains, enabling researchers to dissect the prion-like behavior of Tau and its role in neurotoxicity. Tau dGAE PFFs are instrumental in evaluating therapeutic strategies aimed at inhibiting fibril formation, blocking intercellular transmission, and enhancing aggregate clearance. Their use accelerates the development of targeted interventions and biomarker discovery, positioning them as a cornerstone in translational neurodegeneration research.
Immunogen:
Tau dGAE (297-391) PFFs
Molecular Weight:
10.165 kDa
Purity:
>95%
Purification:
Ion Exchange
Sequence:
MIKHVPGGGSV QIVYKPVDLS KVTSKCGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAE
Shipping Conditions:
Dry Ice
Storage Conditions:
-70[o]C
Supplier:
StressMarq Biosciences
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
TEM of Active Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils (Type 1) (SPR-461)
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE) monomer is combined with truncated tau fragment (AA297-391) (dGAE) Pre-formed Fibrils (Type 1).