Tau Truncated Fragment (AA297-391) (dGAE C322A) Monomers
Product Sizes
100 ug
SPR-445-100UG
2 x 100 ug
SPR-445-2X100UG
5 x 100 ug
SPR-445-5X100UG
About this Product
- SKU:
- SPR-445
- Additional Names:
- Tau dGAE C322A, Tau 297-391 C322A, Tau fragment 297-391 C322A, Truncated Tau C322A, microtubule-associated tau, MAPT, MAP, Tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau fragment
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PBS
- CE/IVD:
- RUO
- Concentration:
- 2 mg/ml
- Extra Details:
- Tau dGAE (297-391) C322A mutant monomers represent a refined molecular tool for studying tau aggregation in neurodegenerative diseases, particularly Alzheimer's disease (AD). This engineered variant of the tau protein, derived from the microtubule-binding domain, incorporates a cysteine-to-alanine substitution at position 322, which significantly alters its aggregation behavior. Unlike wild-type tau, the C322A mutant monomers exhibit enhanced stability and a distinct propensity to form filamentous structures that closely resemble the paired helical filaments (PHFs) found in AD brains. These filaments display a more open C-shaped core, offering a structurally relevant model for investigating disease-specific tau conformations. The mutant's ability to seed further aggregation in vitro underscores its utility in real-time quaking-induced conversion (RT-QuIC) assays and other amplification platforms. Importantly, the C322A mutation reduces disulfide-mediated crosslinking, promoting monomeric stability and controlled filament formation. This facilitates reproducible studies of tau misfolding, aggregation kinetics, and the molecular mechanisms underlying tauopathies. The mutant's behavior also provides insights into the prion-like propagation of tau pathology and supports the development of targeted therapeutics aimed at halting filament spread. In summary, Tau dGAE C322A mutant monomers serve as a powerful and disease-relevant model for dissecting tau aggregation pathways. Their unique structural and biochemical properties make them indispensable in advancing precision medicine approaches for AD and related tauopathies.
- Immunogen:
- Tau dGAE (297-391) C322A Monomers
- Molecular Weight:
- 10.133 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MIKHVPGGGSV QIVYKPVDLS KVTSKAGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAE
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/tau-protein-spr-445/
