Tau Truncated Fragment (AA297-391) (dGAE) Monomers
Product Sizes
100 ug
SPR-444-100UG
2 x 100 ug
SPR-444-2X100UG
5 x 100 ug
SPR-444-5X100UG
About this Product
- SKU:
- SPR-444
- Additional Names:
- Tau dGAE, Tau 297-391, Truncated Tau, Tau fragment 297-391, microtubule-associated tau, MAPT, MAP, Tau-441, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PB pH 7.4
- CE/IVD:
- RUO
- Concentration:
- 2 mg/ml
- Extra Details:
- Tau dGAE (297-391), a core fragment of the microtubule-associated protein tau, is gaining prominence in neurodegenerative disease research due to its intrinsic ability to self-assemble into filamentous aggregates. This monomeric fragment, derived from the C-terminal region of tau, represents a minimal structural unit capable of recapitulating disease-specific filament folds observed in conditions such as Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Unlike full-length tau, dGAE monomers spontaneously aggregate in vitro, forming stable filaments that mimic pathological tau structures found in human brains. These filaments efficiently seed the aggregation of endogenous tau, triggering a cascade of misfolding events that culminate in neurofibrillary tangle formation-a hallmark of tauopathies. The dGAE fragment's aggregation propensity and structural fidelity make it a powerful model for studying tau misfolding and for screening anti-aggregation therapeutics. Recent studies have demonstrated that dGAE-induced tau filaments propagate disease-specific conformations, suggesting a prion-like mechanism of tau spread. Moreover, targeting truncated tau species such as dGAE has shown promise in reducing tau pathology, restoring synaptic function, and improving cognitive outcomes in preclinical models. In summary, Tau dGAE (297-391) monomers serve as critical molecular initiators of tau aggregation and neurotoxicity. Their unique properties position them as valuable tools for mechanistic studies, biomarker development, and the design of targeted interventions in tau-driven neurodegenerative diseases.
- Immunogen:
- Tau dGAE (297-391) Monomers
- Molecular Weight:
- 10.165 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Sequence:
- MIKHVPGGGSV QIVYKPVDLS KVTSKCGSLG NIHHKPGGGQ VEVKSEKLDF KDRVQSKIGS LDNITHVPGG GNKKIETHKL TFRENAKAKT DHGAE
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/tau-protein-spr-444/
