Superoxide Dismutase Monomers
Product Sizes
100 ug
SPR-435-100UG
2 x 100 ug
SPR-435-2X100UG
5 x 100 ug
SPR-435-5X100UG
About this Product
- SKU:
- SPR-435
- Additional Names:
- Superoxide dismutase 1, SOD1, ALS1, IPOA, Cu/Zn superoxide dismutase, Superoxide dismutase [Cu-Zn], hSOD1, SODC, Cytosolic superoxide dismutase, Erythrocuprein, Hemocuprein, Cytocuprein, Indophenoloxidase A
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- PB pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- Superoxide dismutase 1 (SOD1), encoded by the SOD1 gene, is a critical antioxidant enzyme that normally functions as a stable homodimer to neutralize superoxide radicals. However, in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), mutations in SOD1 destabilize its dimeric structure, leading to the formation of toxic monomeric species. SOD1 monomers are increasingly recognized as central players in ALS pathogenesis. These misfolded monomers exhibit a high propensity for aggregation, triggering a cascade of cellular dysfunctions including mitochondrial damage, impaired axonal transport, and activation of apoptotic pathways. Their accumulation in motor neurons contributes to progressive neurodegeneration and loss of motor function. Advanced structural studies have revealed that mutant SOD1 monomers undergo conformational changes that expose hydrophobic regions, promoting aggregation and toxicity. These insights have catalyzed the development of therapeutic strategies aimed at stabilizing SOD1 dimers or preventing monomer formation. Beyond ALS, emerging evidence suggests that SOD1 monomers may influence oxidative stress responses in other neurodegenerative conditions, positioning them as potential biomarkers and therapeutic targets. Understanding their molecular behavior is essential for designing precision interventions that mitigate protein misfolding and neuronal damage. In summary, SOD1 monomers represent a critical nexus in neurodegenerative disease research, offering new opportunities for diagnostics and targeted therapies that address the root causes of neuronal vulnerability.
- Immunogen:
- SOD1 Monomers
- Molecular Weight:
- 15.936 kDa
- Purity:
- >95%
- Purification:
- Ion Exchange
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/sod-protein-spr-435/
