HOP Protein
Product Sizes
50 ug
£269.00
SPR-302-50UG
100 ug
£412.00
SPR-302-100UG
About this Product
- SKU:
- SPR-302
- Additional Names:
- HOP, HSP co chaperone, STIP1, Stress-induced-phosphoprotein 1, Hsp70/Hsp90-organizing
- Application:
- Cell-based/Functional Assay, SDS-PAGE, Western Blot
- Buffer:
- 25mM HEPES pH 7.2, 50mM NaCl, 1mM DTT, 10% glycerol
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Extra Details:
- HOP (HSP70-HSP90 Organizing Protein) is a co-chaperone that facilitates the transfer of client proteins between HSP70 and HSP90, coordinating their folding and maturation. It acts as a scaffold, linking the two chaperone systems and ensuring efficient proteostasis under both normal and stress conditions. In the context of neurodegenerative disease, HOP is essential for managing the folding of proteins involved in neuronal signaling, cytoskeletal integrity, and synaptic function. Its role becomes particularly important in diseases characterized by protein misfolding and aggregation, such as Alzheimer's, Parkinson's, and ALS. HOP's ability to regulate the chaperone cycle influences the fate of neurotoxic proteins like tau and A Alpha-synuclein. Altered HOP expression or function can disrupt this balance, leading to impaired protein clearance and neuronal dysfunction. As such, HOP is a potential therapeutic target for modulating chaperone activity and enhancing neuroprotection in degenerative brain disorders.
- Immunogen:
- HOP Protein
- Molecular Weight:
- ~63 kDa
- Purity:
- >90%
- Purification:
- Affinity Purified
- Sequence:
- MGHHHHHHMEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/hop-protein-spr-302/
