HSP90 beta Protein
Product Sizes
50 ug
£255.00
SPR-102-50UG
100 ug
£392.00
SPR-102-100UG
About this Product
- SKU:
- SPR-102
- Additional Names:
- FLJ26984, HSP84, HSP90, HSP90B, HSPC2, HSPCB
- Application:
- Cell-based/Functional Assay, ELISA, Immunoprecipitation, SDS-PAGE, Surface Plasmon Resonance, Western Blot
- Buffer:
- 20mM Tris, pH7.5, 175 mM NaCl, 0.1 mM EDTA, 10% glycerol, 1 mM DTT
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
- Extra Details:
- HSP90 beta is the constitutively expressed isoform of the HSP90 family and is essential for the maintenance of cellular protein networks. In the nervous system, HSP90 beta supports the folding and maturation of proteins involved in synaptic transmission, cytoskeletal dynamics, and neuronal survival. Emerging evidence links HSP90 beta to neurodegenerative disease mechanisms, particularly through its regulation of tau, A Alpha-synuclein, and other aggregation-prone proteins. Alterations in HSP90 beta expression or function can disrupt neuronal signaling pathways and exacerbate protein misfolding, contributing to the pathogenesis of disorders such as Alzheimer's and Parkinson's disease. HSP90 beta interacts with a broad array of co-chaperones and client proteins, forming cytosolic complexes that buffer cells against proteotoxic stress. Its role in modulating the stability and degradation of neurotoxic proteins makes it a potential therapeutic target for restoring proteostasis and mitigating neurodegeneration.
- Immunogen:
- HSP90 beta Protein
- Molecular Weight:
- ~90 kDa
- Purity:
- >85%
- Purification:
- Affinity Purified
- Sequence:
- MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/protein/hsp90-beta-protein-spr-102/
