p53 Antibody: FITC
Product Sizes
100 ug
SPC-682D-FITC-100UG
About this Product
- SKU:
- SPC-682D-FITC
- Additional Names:
- TP53, Tumor Protein 53, BCC7, LFS1, TRP53, p53 tumor suppressor
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Conjugate:
- FITC
- Concentration:
- 1 mg/ml
- Extra Details:
- p53 (tumor protein 53) is a transcription factor best known for its role in tumor suppression, but it also plays a critical role in neuronal survival, DNA repair, and apoptosis. Often referred to as the "guardian of the genome," p53 maintains genomic stability by regulating cell cycle checkpoints and initiating cell death in response to DNA damage. In the brain, p53 is activated by oxidative stress, excitotoxicity, and mitochondrial dysfunction-key features of neurodegenerative diseases. Overactivation of p53 can lead to excessive neuronal apoptosis, contributing to the progression of Alzheimer's, Parkinson's, and Huntington's disease. Targeting p53 signaling pathways offers a promising strategy to modulate neuronal death and enhance neuroprotection in degenerative conditions.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from the C-terminal of human tumor protein p53.
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
