p53 Antibody
Product Sizes
12 ug
£111.00
SPC-682-12UG
100 ug
£448.00
SPC-682-100UG
About this Product
- SKU:
- SPC-682
- Additional Names:
- TP53, Tumor Protein 53, BCC7, LFS1, TRP53, p53 tumor suppressor
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- CE/IVD:
- Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- p53 (tumor protein 53) is a transcription factor best known for its role in tumor suppression, but it also plays a critical role in neuronal survival, DNA repair, and apoptosis. Often referred to as the "guardian of the genome," p53 maintains genomic stability by regulating cell cycle checkpoints and initiating cell death in response to DNA damage. In the brain, p53 is activated by oxidative stress, excitotoxicity, and mitochondrial dysfunction-key features of neurodegenerative diseases. Overactivation of p53 can lead to excessive neuronal apoptosis, contributing to the progression of Alzheimer's, Parkinson's, and Huntington's disease. Targeting p53 signaling pathways offers a promising strategy to modulate neuronal death and enhance neuroprotection in degenerative conditions.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from the C-terminal of human tumor protein p53.
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.
- Storage Conditions:
- -20[o]C
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.stressmarq.com/products/antibodies/polyclonal-antibodies/p53-antibody-spc-682/
