Amyloid Oligomers (A11) Antibody: ATTO 390
Product Sizes
100 ul
SPC-506D-A390-100UL
About this Product
- SKU:
- SPC-506D-A390
- Additional Names:
- Amyloid Oligomer alpha beta, A11, Amyloid Oligomer AlphaBeta, APP, Amyloid beta A4 protein, ABPP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II, A4, AD1
- Application:
- Dot Blot, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- 640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Conjugate:
- ATTO 390
- Extra Details:
- Amyloid oligomers are soluble, misfolded protein assemblies that represent a critical early stage in the formation of amyloid fibrils. Detected by the conformation-specific A11 antibody, these oligomeric species are increasingly recognized as the most neurotoxic form of amyloid aggregates in neurodegenerative diseases. Unlike mature fibrils, amyloid oligomers disrupt cellular function through membrane permeabilization, oxidative stress, and synaptic impairment. Oligomerization can occur even in non-disease-related proteins under conditions of partial misfolding or denaturation, highlighting the intrinsic amyloidogenic potential of many polypeptides. In pathological contexts, amyloid oligomers are central to the progression of disorders such as Alzheimer's disease (via amyloid-B Beta and tau), Parkinson's disease (via A Alpha-synuclein), and Huntington's disease (via polyglutamine-expanded huntingtin). These toxic intermediates precede the formation of insoluble plaques and tangles, making them valuable biomarkers and therapeutic targets. The A11 antibody has become a powerful tool in neuroscience research, enabling the selective detection of prefibrillar oligomers across diverse amyloidogenic proteins. Its application has advanced our understanding of early aggregation events and their role in synaptic dysfunction and neuronal loss. As the field shifts toward early intervention strategies, amyloid oligomers-and their detection via A11-are at the forefront of neurodegenerative disease research, offering critical insights into disease mechanisms and potential avenues for therapeutic development.
- Host:
- Rabbit
- Immunogen:
- Synthetic molecular mimic of soluble human amyloid beta oligomers
- Purification:
- Protein A Purified
- Reactivities:
- Human, Mouse, Other Species, Rat
- Shipping Conditions:
- Blue Ice
- Specificity:
- Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
- Storage Conditions:
- See Manual
- Supplier:
- StressMarq Biosciences
- Type:
- Antibody: Polyclonal Antibody
