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Antibodies

Aquaporin 2 Antibody

Product Sizes
12 ug
SPC-503-12UG
100 ug
SPC-503-100UG
About this Product
SKU:
SPC-503
Additional Names:
ADH water channel Antibody, AQP 2 Antibody, AQP CD Antibody, AQP-2 Antibody, AQP-CD Antibody, AQP2 Antibody, AQP2_HUMAN Antibody, AQPCD Antibody, Aquaporin 2 collecting duct Antibody, Aquaporin CD Antibody, Aquaporin-2 Antibody, Aquaporin-CD Antibody, Aquaporin2 Antibody, Aquaporine 2 Antibody, Collecting duct water channel protein Antibody, MGC34501 Antibody, Water channel aquaporin 2 Antibody, Water channel protein for renal collecting duct Antibody, WCH CD Antibody, WCH-CD Antibody, WCHCD Antibody
Application:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
CE/IVD:
RUO
Clonality:
Polyclonal
Concentration:
1 mg/ml
Extra Details:
Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell (3). Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) (4).
Host:
Rabbit
Immunogen:
Produced against the C-terminal peptide (Sequence N-CLKGLEPDTDWEEREVRRRQ) of rat aquaporin 2
Purification:
Protein A Purified
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Specificity:
Detects ~28.8kDa. May detect larger glycosylated bands ~35-50kDa.
Storage Conditions:
-20[o]C
Supplier:
StressMarq Biosciences
Type:
Antibody: Polyclonal Antibody
Immunohistochemistry analysis using Rabbit Anti-Aquaporin 2 Polyclonal Antibody (SPC-503). Tissue: kidney tissue. Species: Rat. Fixation: 4% paraformaldehyde-lysine-periodate. Primary Antibody: Rabbit Anti-Aquaporin 2 Polyclonal Antibody (SPC-503) at 1:200 for 75 min at RT. Secondary Antibody: FITC Goat Anti-Rabbit (green) for 1 hour at RT. 4 um cryostat sections.
Western blot analysis of Rat kidney inner medullary homogenates showing detection of Aquaporin 2 protein using Rabbit Anti-Aquaporin 2 Polyclonal Antibody (SPC-503). Primary Antibody: Rabbit Anti-Aquaporin 2 Polyclonal Antibody (SPC-503) at 1:2000. Showing glycosylated and non-glycosylated bands.